Proteomics and metabolomics in diagnosis and scoring of vascular calcifications in chronic kidney disease
 
 
 

RENART application

private documents

About the project

Contractor: The Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI)

Program: Partnerships in S&T priority domains - Joint Applied Research Projects

Domain: Health

Coordinator: Fundeni Clinical Institute

Contract no. 93/2012

Duration: August 2012 - December 2016

State budget: 3,000,000 lei

Co-financing budget: 250,000 lei

 

Objectives

The overall objective of the Renart project is to evaluate new biomarkers of vascular calcification in chronic kidney disease from research based on proteomics, molecular and cellular biology. The project also aims to develop a computer assisted score for vascular calcifications using a comprehensive approach, with consequences on prognosis and therapeutic interventional strategies at patients with chronic kidney disease.

Specific objectives

  • Analysis of biomarkers for arterial calcification in patients with chronic kidney disease from research based on proteomics, molecular and cellular biology.
  • Analysis of associations between various biomarkers and severity of arterial calcification in the intima and media in chronic kidney disease.Elaborarea unui model matematic pentru scorificarea calcific─ârilor vasculare.
  • Development of a mathematical model for vascular calcification scoring.
  • Development of a computer-aided score for assessing vascular calcification in chronic kidney disease - ArterioTest.
  • Elaboration of a user manual, transfer of protocols and technologies to ITC and to clinical users by organizing thematic workshops and conferences.
  • Development of a Network of Excellence connected to the national and international study groups on bone, kidney, heart, and supported by scientific publications, organization of workshops and conferences.
  • Development of a website to facilitate the communication among the participating centers and the dissemination of project's results.